Data security is critical in clinical research and medical registries. PRJCTS and LEDIDI™ is compliant with the EU General Data Protection Regulation (GDPR) and the US Health Insurance Portability and Accountability Act (HIPAA). The raw data is encrypted end-to-end (in transit and at rest), and user authentication is secured by two-factor authentication. In research collaborations, project members can be assigned privileges at a detailed level so that multicenter studies are truly collaborative, but at the same time individual raw data remain protected. For example, project members can be given the permission to analyze data at an aggregated level without having access to raw data from individual patients.